Key result
Repetitive oral administration of SM-130686 to rats significantly increased fat free mass by an amount almost equal to the gain in body weight.
Population
Cultured rat pituitary cells, human GHS receptor 1a, and rat models
Design
Preclinical
Follow-up
9 days
Authors
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Animal data support testing oral GH secretagogues for lean mass; human translation remains untested.
SM-130686 is a novel orally active growth hormone secretagogue that effectively stimulates GH release and increases fat-free mass in rat models.
Nagamine et al. (2001) studied this question. SM-130686 was evaluated on Body weight and fat free mass. Repetitive oral administration of SM-130686 to rats significantly increased fat free mass by an amount almost equal to the gain in body weight.
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