Key result
Elevated uric acid levels (6.10-9.80 mg/dL) were significantly associated with increased brachial-ankle pulse wave velocity compared to the lowest quantile (OR 143.13), demonstrating a non-linear positive correlation.
Why the study?
The association between uric acid and brachial-ankle pulse wave velocity has not been well clarified.
Is elevated uric acid associated with increased brachial-ankle pulse wave velocity in individuals undergoing medical health examinations?
Cross-Sectional (n=912)
No
Is elevated uric acid associated with increased brachial-ankle pulse wave velocity in individuals undergoing medical health examinations?
Odds Ratio: 143.13 (95% CI 0.75–285.51)
p-value: p=0.0497
Elevated uric acid levels are non-linearly and positively associated with brachial-ankle pulse wave velocity, suggesting a potential role as a predictor of atherosclerosis.
UA elevation was associated with higher baPWV; leaves open whether UA reduction improves arterial stiffness.
At present, the association between uric acid (UA) and brachial-ankle pulse wave velocity (baPWV) has not been well clarified. This study is the second analysis based on a cross-sectional study. 912 participants (average age is 51.5 ± 9.6 years) who underwent medical health examinations were included in this study, UA levels and baPWV were measured. Participants were divided into four groups according to UA levels (Quantile 1: 2.00-4.10 mg/dL; Quantile 2: 4.20-5.20 mg/dL; Quantile 3: 5.30-6.00 mg/dL and Quantile 4: 6.10-9.80 mg/dL), and the differences of baPWV between the four groups were compared. Univariate analysis showed a positive correlation between UA and baPWV [(Quantile 2 vs Quantile 1: 8.85 (-36.05, 53.75); Quantile 3 vs Quantile 1: 60.32 (13.22, 107.42) and Quantile 4 vs Quantile 1: 80.34 (36.19, 124.49)]. After adjusting for confounding factors, the positive correlation between UA and baPWV still exists [(Quantile 2 vs Quantile 1: -9.92 (-60.16, 40.32); Quantile 3 vs Quantile 1: 82.34 (4.00, 160.68) and Quantile 4 vs Quantile 1: 143.13 (0.75, 285.51)]. Furthermore, curve fitting showed that UA and baPWV had a non-linear positive correlation. In conclusion, elevated UA were associated with baPWV, suggesting that UA could be used as a predictor of atherosclerosis.
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Luo et al. (2020) conducted a cross-sectional in Healthy adults (health check-ups) (n=912). Uric acid vs. Quantile 1 (2.00-4.10 mg/dL) was evaluated on Brachial-ankle pulse wave velocity (baPWV) (OR 143.13, 95% CI 0.75, 285.51, p=0.0497). Elevated uric acid levels (6.10-9.80 mg/dL) were significantly associated with increased brachial-ankle pulse wave velocity compared to the lowest quantile (OR 143.13), demonstrating a non-linear positive correlation.
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