Key result
The AST to ALT ratio demonstrated a non-linear relationship with arterial stiffness in Japanese adults without fatty liver, positively correlating with brachial-ankle pulse wave velocity when the ratio (per 0.1 change) exceeded 13.1 (β 10.9).
Why the study?
There were few investigations evaluating the relationship between the aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio and brachial-ankle pulse wave velocity (baPWV).
Is the AST to ALT ratio associated with brachial-ankle pulse wave velocity (baPWV) in a Japanese population without fatty liver?
Population
646 Japanese men and women without fatty liver aged 24-84 years old
Comparison
AST/ALT ratio levels
Design
Cross-sectional study
Authors
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Association with higher baPWV in cross-sectional data; leaves open causal direction and requires longitudinal confirmation before clinical relevance.
Cross-Sectional (n=646)
No
Is the AST to ALT ratio associated with brachial-ankle pulse wave velocity (baPWV) in a Japanese population without fatty liver?
Effect estimate: β 10.9 (95% CI 3.3 to 18.6)
p-value: p=0.005
The AST/ALT ratio has a non-linear relationship with arterial stiffness (baPWV) in a Japanese population without fatty liver, with a positive correlation when the ratio is less than 5.6.
Liu et al. (2018) conducted a cross-sectional in Non-fatty liver (n=646). AST to ALT ratio vs. AST to ALT ratio < 13.1 (per 0.1 change) was evaluated on Brachial-ankle pulse wave velocity (baPWV) (β 10.9, 95% CI 3.3 to 18.6, p=0.005). The AST to ALT ratio demonstrated a non-linear relationship with arterial stiffness in Japanese adults without fatty liver, positively correlating with brachial-ankle pulse wave velocity when the ratio (per 0.1 change) exceeded 13.1 (β 10.9).
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