Key result
Concomitant use of aspirin with ketorolac was associated with increased renal morbidity in young post-cardiac surgical infants.
Why the study?
Does concomitant aspirin use increase the risk of acute kidney injury in infants receiving ketorolac after cardiac surgery?
Case-Control
Does concomitant aspirin use increase the risk of acute kidney injury in infants receiving ketorolac after cardiac surgery?
The concomitant use of aspirin and ketorolac in infants following cardiac surgery is associated with an increased risk of acute kidney injury.
May warrant caution with combined aspirin-ketorolac in post-cardiac surgery infants; hypothesis-generating and requires prospective confirmation.
We aimed to identify the risk factors for acute kidney injury in infants who have received ketorolac after a cardiac surgical procedure by identifying patients with a > or = 50% increase in serum creatinine from baseline and matching them by age with three controls that had < 50% increase in serum creatinine. Significant differences in primary surgical procedure, baseline serum creatinine, and concomitant aspirin use were noted. We conclude that the concomitant use of aspirin with ketorolac is associated with increased renal morbidity in young post-cardiac surgical infants.
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Moffett et al. (2012) conducted a case-control in Acute kidney injury. Concomitant aspirin use with ketorolac vs. Ketorolac without concomitant aspirin was evaluated on Acute kidney injury (≥ 50% increase in serum creatinine from baseline). Concomitant use of aspirin with ketorolac was associated with increased renal morbidity in young post-cardiac surgical infants.
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