Depression, health-related quality of life and life satisfaction in patients with heart failure
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Key result
Moderate-to-severe depressive symptoms in patients with heart failure were associated with significantly lower health-related quality of life compared to no depressive symptoms (EQ-5D-3L index 0.5 vs 0.7).
Why the study?
The PHQ9 effectively identifies HF patients at risk for lower HRQoL, but the relationships between varying levels of depressive symptomatology and HRQoL, life satisfaction, disease severity, and risk factors remained to be compared.
Are different levels of depressive symptomatology associated with differences in health-related quality of life and life satisfaction in patients with heart failure?
Population
Patients with HF identified from screening 1851 general population subjects aged >55 years
Comparison
None vs mild vs moderate-to-severe depressive symptomatology by PHQ9 score
Design
Cross-sectional study
Authors
Discussion
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Implication
Mild depressive symptoms were associated with worse HRQoL in HF; hypothesis-generating for screening, prospective trials needed before practice change.
Key Points
- This research aims to explore the relationship between depression, health-related quality of life, and life satisfaction in patients with heart failure.
- Conducted a cross-sectional study with 930 heart failure patients screened for depressive symptoms using the PHQ9.
- Utilized various assessment tools including ShortForm 12 Health Survey (SF12), EQ5D3L, and Satisfaction With Life Scale (SWLS).
- Divided patients into three groups based on severity of depressive symptoms and analyzed differences in health-related quality of life and satisfaction.
- Significant differences in New York Heart Association (NYHA) status (p<0.001) across depressive symptom groups.
- The non-depressed group showed better health-related quality of life (p=0.05 to 0.001) and life satisfaction (p<0.05) compared to those with mild and moderate-to-severe depression.
- Patients with clinically non-significant depressive symptoms still exhibited impaired psychosocial status.
Study Design
Type
Cross-Sectional (n=221)
Structured PICO
Are different levels of depressive symptomatology associated with differences in health-related quality of life and life satisfaction in patients with heart failure?
P
Population
221 adults over 55 years of age with confirmed heart failure, evaluated cross-sectionally to assess the association between depressive symptoms and health-related quality of life.
O
Outcome
Health-related quality of life (SF12, EQ5D3L), satisfaction with life (SWLS), and disease severity variables across different levels of depressive symptomatology (PHQ9)patient reported
Main Result
Absolute Event Rate: 0.5% vs 0.7%
p-value: p=<0.001
Even mild, clinically non-significant levels of depressive symptoms in heart failure patients are associated with significantly impaired psychosocial status and lower life satisfaction.
Limitations
- Cross-sectional design precludes determining causality
- Depression estimated via self-report questionnaire (PHQ-9) rather than a diagnostic interview
- Potential unmeasured confounding factors
- Did not evaluate the potential effect of frailty
Cite This Study
Kobe et al. (2024) conducted a cross-sectional in Heart failure (n=221). Depressive symptomatology vs. No depressive symptomatology was evaluated on Health-related quality of life (EQ-5D-3L index score) (p=<0.001). Moderate-to-severe depressive symptoms in patients with heart failure were associated with significantly lower health-related quality of life compared to no depressive symptoms (EQ-5D-3L index 0.5 vs 0.7).
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