Key result
N-RAP binds specifically to actin, vinculin, and talin, supporting its hypothesized role in anchoring terminal actin filaments of the myofibril to the membrane.
Population
Myofibrillar and junctional proteins and recombinant fragments of N-RAP
Design
Preclinical
Authors
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N-RAP binds junctional proteins in vitro; leaves open its anchoring role at cardiac intercalated disks pending functional validation.
N-RAP interacts specifically with actin, vinculin, and talin, supporting its hypothesized role in anchoring terminal actin filaments to the sarcolemma.
Luo et al. (1999) studied this question. N-RAP recombinant fragments was evaluated on Binding to myofibrillar and junctional proteins. N-RAP binds specifically to actin, vinculin, and talin, supporting its hypothesized role in anchoring terminal actin filaments of the myofibril to the membrane.
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