Early diastolic mitral annular velocity < 3.5 cm/s measured by tissue Doppler imaging provided incremental prognostic value for cardiac death over standard variables (P=0.043).
Cohort (n=252)
Does early diastolic mitral annulus velocity measured by TDI provide incremental prognostic value for cardiac death in hypertensive patients with LV hypertrophy?
Early diastolic mitral annulus velocity (Em) measured by TDI provides incremental prognostic value beyond standard clinical and echocardiographic parameters for predicting cardiac death in treated hypertensive patients.
p-value: p=0.043
OBJECTIVES: We sought to determine the prognostic value of left ventricular (LV) mitral annular velocities measured by tissue Doppler imaging (TDI) in hypertensive patients with echocardiographic evidence of LV hypertrophy. BACKGROUND: Echo LV hypertrophy and LV geometry provide additional predictive value of all-cause mortality beyond traditional cardiovascular risk factors. Limited data exist regarding the predictive value of TDI velocities for cardiovascular risk stratification in treated hypertensive patients. METHODS: Two-dimensional and Doppler echocardiograms were obtained in 252 consecutive subjects, including 174 subjects with systemic hypertension and 78 age-matched normal subjects. The end point was cardiac death in subsequent median follow-up of 19 months. RESULTS: Nineteen patients (7.54%) died of cardiac causes. The TDI mitral annulus systolic velocity and the early diastolic mitral annular velocity (Em) were significantly lower in the non-survivors (all P 1.4 cm and either PN or RFP (P = 0.043). CONCLUSIONS: Early diastolic mitral annulus velocity measured by TDI provides prognostic information, incremental to clinical data and standard echocardiographic variables, for risk stratification of hypertensive patients under treatment.
Mei et al. (2005) conducted a cohort in Systemic hypertension and left ventricular hypertrophy (n=252). Early diastolic mitral annular velocity (Em) < 3.5 cm/s vs. Em ≥ 3.5 cm/s was evaluated on Cardiac death (p=0.043). Early diastolic mitral annular velocity < 3.5 cm/s measured by tissue Doppler imaging provided incremental prognostic value for cardiac death over standard variables (P=0.043).