Key result
Elevated MMP-2 (>767.0 ng/mL) and AF duration >5 months were significantly associated with refractory atrial fibrillation after cardioversion (OR 4.84 and 15.32, respectively).
Why the study?
Do baseline matrix metalloproteinase-2 (MMP-2) levels predict long-term maintenance of sinus rhythm after cardioversion in patients with atrial fibrillation?
Population
102 patients with atrial fibrillation undergoing pharmacological or electrical cardioversion
Design
Cohort
Authors
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May aid risk stratification for refractory AF post-cardioversion; hypothesis-generating and requires prospective validation.
Cohort (n=102)
Do baseline matrix metalloproteinase-2 (MMP-2) levels predict long-term maintenance of sinus rhythm after cardioversion in patients with atrial fibrillation?
Odds Ratio: 4.84
Elevated baseline MMP-2 levels and AF duration >5 months are strong predictors of failure to maintain sinus rhythm after cardioversion.
Kato et al. (2009) conducted a cohort in atrial fibrillation (n=102). Elevated MMP-2 (>767.0 ng/mL) vs. Lower MMP-2 levels was evaluated on Refractory atrial fibrillation (OR 4.84). Elevated MMP-2 (>767.0 ng/mL) and AF duration >5 months were significantly associated with refractory atrial fibrillation after cardioversion (OR 4.84 and 15.32, respectively).
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