Key result
Ribavirin 5'-triphosphate selectively and competitively inhibited influenza virus ribonucleic acid polymerase in a cell-free assay, whereas ribavirin and its 5'-monophosphate had no effect.
Ribavirin 5'-triphosphate is identified as the active metabolite of ribavirin responsible for inhibiting influenza virus RNA polymerase.
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Ribavirin triphosphate shows selective polymerase inhibition in vitro; leaves open its potential as an anti-influenza agent pending in vivo studies.
Eriksson et al. (1977) studied Influenza virus. Ribavirin 5'-triphosphate (RTP) vs. Ribavirin and its 5'-monophosphate was evaluated on Inhibition of influenza virus ribonucleic acid polymerase. Ribavirin 5'-triphosphate selectively and competitively inhibited influenza virus ribonucleic acid polymerase in a cell-free assay, whereas ribavirin and its 5'-monophosphate had no effect.
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