Malononitrile on rare form: Highly enantioselective Michael addition of malononitrile to vinylogous imine intermediates 2, generated in situ from arylsulfonyl indoles 1, is described (see scheme). This protocol provides easy and convenient access to valuable 3-indolyl derivatives 3 in high yields and enantioselectivities. A possible catalytic mechanism is proposed.
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Jing et al. (2010) studied this question.
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