Effects of aerobic interval training and continuous training on cellular markers of endothelial integrity in coronary artery disease: a SAINTEX-CAD substudy
Key result
In CAD patients, 12 weeks of aerobic exercise training did not alter cellular markers of endothelial integrity, though baseline EMPs inversely correlated with FMD improvement (rho = -0.374, P=0.001).
Why the study?
Does aerobic interval training compared to continuous training improve cellular markers of endothelial integrity and endothelial function in patients with stable coronary artery disease?
Population
200 stable coronary artery disease patients with left ventricular ejection fraction > 40%, mean age 58.4 ±…
Comparison
Supervised 12-week rehabilitation program of… vs Supervised 12-week rehabilitation program of…
Design
RCT, 1:1 base
Follow-up
12 weeks
Authors
Discussion
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Implication
Aerobic exercise does not alter endothelial markers in CAD; baseline EMP-FMD correlation is hypothesis-generating and requires confirmation.
Study Design
Type
RCT (n=200)
Randomization
1:1
Multicenter
Yes
Structured PICO
Does aerobic interval training compared to continuous training improve cellular markers of endothelial integrity and endothelial function in patients with stable coronary artery disease?
P
Population
200 patients with stable coronary artery disease (LVEF > 40%, 90% male, mean age 58.4 years) randomized to a 12-week supervised rehabilitation program of aerobic interval or continuous training.
I
Intervention
Supervised 12-week rehabilitation program of aerobic interval training on a bicycle.
C
Comparator
Supervised 12-week rehabilitation program of aerobic continuous training on a bicycle.
O
Outcome
Cellular markers of endothelial integrity (circulating CD34(+)/KDR(+)/CD45dim endothelial progenitor cells, CD31(+)/CD3(+)/CXCR4(+) angiogenic T cells, and CD31(+)/CD42b(-) endothelial microparticles) and endothelial function assessed by flow-mediated dilation (FMD) of the brachial artery at 12 weeks.surrogate
In patients with stable CAD, improvements in endothelial function following exercise training are not mediated by changes in circulating endothelial progenitor cells or angiogenic T cells.
Cite This Study
Craenenbroeck et al. (2015) conducted an RCT in Stable coronary artery disease (n=200). Aerobic interval training vs. Aerobic continuous training was evaluated on Cellular markers of endothelial integrity (EPCs, angiogenic T cells, and EMPs). In CAD patients, 12 weeks of aerobic exercise training did not alter cellular markers of endothelial integrity, though baseline EMPs inversely correlated with FMD improvement (rho = -0.374, P=0.001).