A new oxyA gene replacement mutant of Amycolatopsis mediterranei enabled us to isolate two peptides, SP-1132 (1) and SP-1294 (2), which only have one diaryl ether bridge. These vancomycin-type structures provide further insight into the oxidative ring-bridging steps in their biosynthesis.
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Bischoff et al. (2001) studied this question.
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