Why the study?
Does dietary nitrate reduce blood pressure in patients with hypertension?
Population
68 patients with hypertension aged 18 to 85 years, stratified into drug-naive (n=34) and treated (n=34)
Comparison
Dietary nitrate for 4 weeks vs Placebo for 4 weeks
Design
RCT, Stratified randomization of drug-naive and treated patients…
Follow-up
4 weeks
Key result
Daily dietary nitrate supplementation for 4 weeks significantly reduced clinic blood pressure by 7.7/2.4 mm Hg (P<0.001 and P=0.050) in patients with hypertension.
Authors
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Supports dietary nitrate supplementation for BP lowering in hypertension; confirms efficacy via ambulatory monitoring in RCT.
RCT (n=68)
double-blind
stratified randomization
Does dietary nitrate reduce blood pressure in patients with hypertension?
Mean Difference: 7.7 (95% CI 3.6–11.8)
p-value: p=<0.001 and 0.050
Daily dietary nitrate supplementation via beetroot juice provides significant and sustained blood pressure reduction in hypertensive patients.
Kapil et al. (2014) conducted an RCT in hypertension (n=68). Dietary nitrate (beetroot juice) vs. Placebo (nitrate-free beetroot juice) was evaluated on change in clinic, ambulatory, and home BP compared with placebo (MD 7.7/2.4 mm Hg (clinic BP reduction), 95% CI 3.6-11.8/0.0-4.9, p=<0.001 and 0.050). Daily dietary nitrate supplementation for 4 weeks significantly reduced clinic blood pressure by 7.7/2.4 mm Hg (P<0.001 and P=0.050) in patients with hypertension.