Key result
Higher admission procalcitonin levels independently predicted intra-ICCU mortality, 1-year MACE, and total mortality in patients with acute coronary syndromes.
Why the study?
Do admission procalcitonin levels predict intra-ICCU mortality, 1-year MACE, and total mortality in patients with acute coronary syndromes?
Cohort (n=247)
No
Do admission procalcitonin levels predict intra-ICCU mortality, 1-year MACE, and total mortality in patients with acute coronary syndromes?
Admission procalcitonin levels serve as an independent predictor of short- and long-term mortality and MACE in patients with acute coronary syndromes.
Supports risk stratification in ACS but should not yet change practice; leaves open need for prospective validation and RCTs.
BACKGROUND: Available evidence on the prognostic role of procalcitonin levels in acute coronary syndromes (ACS) is so far controversial. AIMS: To evaluate the association between procalcitonin, major cardiovascular events (MACE) and total mortality in acute coronary syndromes. METHODS: Procalcitonin levels were measured in 247 patients admitted to our Intensive Cardiac Care Unit (ICCU) with ACS. Three subgroups were considered according to procalcitonin levels. RESULTS: At Cox regression analysis, procalcitonin levels were both an unadjusted and an adjusted predictor (corrected for diagnosis and TnI) of intra-ICCU mortality and of 1-year follow-up MACE and total mortality. CONCLUSIONS: In ACS, admission procalcitonin values identify a "higher risk" group of patients for short and long-term mortality.
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Picariello et al. (2011) conducted a cohort in Acute coronary syndromes (n=247). Admission procalcitonin levels vs. Lower procalcitonin levels was evaluated on Intra-ICCU mortality, 1-year follow-up MACE, and total mortality. Higher admission procalcitonin levels independently predicted intra-ICCU mortality, 1-year MACE, and total mortality in patients with acute coronary syndromes.
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