Key result
A high lactate/albumin ratio (≥0.597) was independently associated with an increased risk of 30-day all-cause mortality in patients with acute respiratory failure (HR 1.56).
Why the study?
The role of the lactate/albumin ratio as an independent prognostic factor for all-cause mortality in patients with acute respiratory failure remained to be clarified.
Does the lactate/albumin ratio (LAR) predict 30-day all-cause mortality better than individual components or SOFA score in patients with acute respiratory failure?
Population
2170 patients with ARF in Medical Information Mart for Intensive Care Database III
Comparison
LAR vs albumin, lactate, or SOFA score
Design
Retrospective analysis
Follow-up
30-day
Authors
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May aid risk stratification in acute respiratory failure; leaves open prospective validation beyond existing scores.
Observational (n=2,170)
No
Does the lactate/albumin ratio (LAR) predict 30-day all-cause mortality better than individual components or SOFA score in patients with acute respiratory failure?
Hazard Ratio: 1.56 (95% CI 1.33–1.83)
Absolute Event Rate: 46.66% vs 26.49%
p-value: p=<0.001
The lactate/albumin ratio is an easily obtainable biomarker that modestly outperforms lactate alone, albumin alone, and the SOFA score in predicting 30-day mortality among patients with acute respiratory failure.
Lu et al. (2021) conducted an observational in Acute respiratory failure (n=2,170). High lactate/albumin ratio (≥0.597) vs. Low lactate/albumin ratio (<0.597) was evaluated on 30-day all-cause mortality (HR 1.56, 95% CI 1.33-1.83, p=<0.001). A high lactate/albumin ratio (≥0.597) was independently associated with an increased risk of 30-day all-cause mortality in patients with acute respiratory failure (HR 1.56).
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