Key result
Cyclophilin D deficiency altered murine platelet activation responses and markedly accelerated thrombosis in a model of carotid artery photochemical injury.
Why the study?
Does cyclophilin D deficiency alter platelet activation and arterial thrombosis in murine models?
Does cyclophilin D deficiency alter platelet activation and arterial thrombosis in murine models?
Cyclophilin D and the mitochondrial permeability transition pore act as critical regulators of platelet activation and provide a novel negative-feedback mechanism regulating arterial thrombosis.
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May identify MPTP as antiplatelet target; leaves open translation from murine models to human thrombosis.
Jobe et al. (2007) studied Platelet activation and thrombosis. Cyclophilin D (CypD) deficiency vs. Normal CypD expression was evaluated on Platelet activation responses and thrombosis. Cyclophilin D deficiency altered murine platelet activation responses and markedly accelerated thrombosis in a model of carotid artery photochemical injury.
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