Key result
The force per motor of the slow myosin isoform was approximately three times smaller than that of the fast isoform (1.89 vs 5.35 pN).
Population
Permeabilised fibres from slow and fast skeletal muscles of the rabbit
Comparison
Fast sarcomere-level mechanical methods during… vs Slow versus fast skeletal muscle fibres
Design
Preclinical
Authors
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No immediate clinical implications; leaves open how isoform force differences shape muscle performance in disease.
Absolute Event Rate: 1.89% vs 5.35%
The stiffness and force of the slow myosin isoform are three times smaller than those of the fast isoform, suggesting that myosin motor stiffness is a key determinant of functional diversity between skeletal muscles.
Percario et al. (2017) studied this question. Slow myosin isoform (MHC-1) vs. Fast myosin isoform (MHC-2X) was evaluated on Force per motor (F0). The force per motor of the slow myosin isoform was approximately three times smaller than that of the fast isoform (1.89 vs 5.35 pN).
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