Key result
Very low-dose subcutaneous vitamin K was more effective than withholding warfarin in reducing high INRs, with a mean INR change of -0.72 versus -0.08 (p=0.001).
Why the study?
Does very low-dose subcutaneous vitamin K reduce high INRs more effectively than withholding warfarin in postoperative joint surgery patients?
Cohort (n=139)
No
Does very low-dose subcutaneous vitamin K reduce high INRs more effectively than withholding warfarin in postoperative joint surgery patients?
Answers are grounded in this paper and cite their sources.
Very low-dose subcutaneous vitamin K is significantly more effective than simply withholding warfarin for rapidly correcting above-target INRs in postoperative orthopedic patients.
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Possidente et al. (2001) conducted a cohort in Above-target INR during postoperative warfarin therapy (n=139). Very low-dose subcutaneous vitamin K vs. Withholding warfarin was evaluated on Change in INR from the day of intervention (day 1) to the next day (day 2) (p=0.001). Very low-dose subcutaneous vitamin K was more effective than withholding warfarin in reducing high INRs, with a mean INR change of -0.72 versus -0.08 (p=0.001).
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