Key result
Proton pump inhibitors may be associated with cardiovascular complications such as myocardial infarction and stroke, though a definitive causal relationship remains unestablished.
Why the study?
Long-term use and inappropriate prescribing of proton pump inhibitors have prompted the reassessment of their potential cardiovascular adverse effects.
Do proton pump inhibitors increase the risk of cardiovascular complications?
Do proton pump inhibitors increase the risk of cardiovascular complications?
While PPIs are associated with cardiovascular complications in some observational studies, a causal relationship remains unproven, highlighting the need for careful patient screening and deprescribing when indications are no longer met.
Proton pump inhibitors (PPIs) are among the most extensively prescribed medications internationally for gastroesophageal reflux disease treatment and the prevention of gastrointestinal bleeding. Their efficiency, ease of availability, and low side effect profile offer several advantages over other treatment modalities. Long-term use and inappropriate prescribing habits have increased the presence of this class of drugs, prompting several studies to reassess their adverse effects. This article explored the possibility of a relationship between PPIs and cardiovascular adverse effects while highlighting the current prescription guidelines for PPIs. We further examined the need for more research into the etiology of PPI-related cardiovascular adverse effects and strategies to alleviate these risks.
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Sarnaik et al. (2021) conducted a review in Patients using proton pump inhibitors. Proton pump inhibitors (PPIs) vs. Non-PPI users, H2 antagonists, or placebo was evaluated on Cardiovascular complications (myocardial infarction, transient ischemic attacks, cardiovascular death). Proton pump inhibitors may be associated with cardiovascular complications such as myocardial infarction and stroke, though a definitive causal relationship remains unestablished.
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