Key result
Low cardiorespiratory fitness combined with exercise-induced ST segment depression was associated with a 4.8-fold higher risk of sudden cardiac death in men (HR 4.8; 95% CI 2.9-7.9).
Why the study?
Does the combination of low cardiorespiratory fitness and exercise-induced ST segment depression predict sudden cardiac death in men?
Cohort (n=2,328)
Does the combination of low cardiorespiratory fitness and exercise-induced ST segment depression predict sudden cardiac death in men?
The combination of low cardiorespiratory fitness and exercise-induced ST segment depression identifies men at markedly increased risk for sudden cardiac death.
Answers are grounded in this paper and cite their sources.
Combining low CRF and ST depression may refine SCD prediction in middle-aged men; hypothesis-generating for risk models, needs validation before practice change.
OBJECTIVE: The aim of this study was to investigate whether information on both cardiorespiratory fitness (CRF) and exercise-induced ST segment depression improves the prediction of sudden cardiac death (SCD) in men. METHODS: The study was based on a population sample of 2328 men aged 42-60 years, who were followed up for on average 19 years. CRF was assessed with maximal exercise test using respiratory gas analysis, expressed in metabolic equivalents (METs) and dichotomised at eight METs. Exercise-induced ST segment depression was defined as 1 mm ST segment depression in ECG. RESULTS: Altogether 165 SCDs occurred during the follow-up. Men with low CRF (<8 METs) and exercise-induced ST segment depression had 4.8-fold (95% CI 2.9 to 7.9) higher risk of SCD than men with high CRF and without exercise-induced ST segment depression (p=0.013 for interaction) after adjustment for other cardiovascular risk factors. Men with high CRF and exercise-induced ST segment depression did not have a statistically significantly higher risk of SCD (HR 1.9, 95% CI 0.9 to 3.8) than men with high CRF and without exercise-induced ST segment depression. CONCLUSIONS: The combination of low CRF and exercise-induced ST segment depression was associated with a markedly increased risk of SCD in men.
No takes yet. Share an insight, caveat, or question.
Hagnäs et al. (2016) conducted a cohort in Sudden cardiac death (n=2,328). Low cardiorespiratory fitness (<8 METs) and exercise-induced ST segment depression vs. High cardiorespiratory fitness without exercise-induced ST segment depression was evaluated on Sudden cardiac death (HR 4.8, 95% CI 2.9-7.9, p=0.013 for interaction). Low cardiorespiratory fitness combined with exercise-induced ST segment depression was associated with a 4.8-fold higher risk of sudden cardiac death in men (HR 4.8; 95% CI 2.9-7.9).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: