Key result
Higher cardiorespiratory fitness and heart rate recovery were independently associated with a reduced risk of sudden cardiac death (HR 0.69, 95% CI 0.52-0.93 and HR 0.74, 95% CI 0.58-0.95).
Why the study?
It was unclear whether cardiorespiratory fitness and heart rate recovery associate with sudden cardiac death risk independently of left ventricular ejection fraction.
Do cardiorespiratory fitness and heart rate recovery predict sudden cardiac death independently of left ventricular ejection fraction in patients referred for exercise testing?
Population
3776 patients without pacemakers undergoing exercise testing on a cycle ergometer
Comparison
Cardiorespiratory fitness and heart rate recovery levels
Design
Prospective clinical study
Follow-up
Median 9.1 years
Authors
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May inform SCD risk stratification; leaves open whether fitness interventions reduce events.
Cohort (n=3,776)
Do cardiorespiratory fitness and heart rate recovery predict sudden cardiac death independently of left ventricular ejection fraction in patients referred for exercise testing?
Hazard Ratio: 0.69 (95% CI 0.52–0.93)
p-value: p=<0.01
Cardiorespiratory fitness and heart rate recovery are strong, independent predictors of sudden cardiac death, providing prognostic value beyond left ventricular ejection fraction.
Hernesniemi et al. (2019) conducted a cohort in Patients referred to clinical exercise testing (n=3,776). Cardiorespiratory fitness (CRF) and heart rate recovery (HRR) vs. 1 SD lower CRF/HRR was evaluated on Sudden cardiac death (SCD) (HR 0.69, 95% CI 0.52-0.93, p=<0.01). Higher cardiorespiratory fitness and heart rate recovery were independently associated with a reduced risk of sudden cardiac death (HR 0.69, 95% CI 0.52-0.93 and HR 0.74, 95% CI 0.58-0.95).
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