Why the study?
Does single-pill triple therapy with an angiotensin converting enzyme inhibitor, a calcium channel blocker, and a statin reduce major cardiovascular events and improve adherence in hypertensive patients with dyslipidemia?
Does single-pill triple therapy with an angiotensin converting enzyme inhibitor, a calcium channel blocker, and a statin reduce major cardiovascular events and improve adherence in hypertensive patients with dyslipidemia?
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Single-pill triple therapy combining an ACE inhibitor, calcium channel blocker, and statin improves adherence and significantly reduces major cardiovascular events in patients with coexisting hypertension and dyslipidemia.
Arterial hypertension and dyslipidemia often coexist and constitute major risk factors of ischemic heart disease.Aggressive treatment of both comorbidities is of paramount importance to decrease global risk.Low adherence is a determinant of poor risk factor control and increases adverse cardiovascular outcomes.Regarding treatment of hypertension, combination therapy is superior in achieving target BP values compared to up-titrating monotherapy and it is recommended in hypertension guidelines.The combined use of drugs in a single pill formulation increases adherence and reduces cardiovascular risk.Our review of the literature indicates that triple therapy with an angiotensin converting enzyme inhibitor, a calcium channel blocker and a statin is associated with a significant reduction in major cardiovascular events.This is attributed to synergy at the vascular, and is translated into efficacy at the clinical level.
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Vlachopoulos et al. (2017) conducted a review in Hypertension and dyslipidemia. Combination therapy (antihypertensives and statins) was evaluated.
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