Key result
In women, the C-allele of AGTR1 was associated with a thicker carotid intima-media thickness (P=0.03), and the T-allele of ADD1 was associated with a smaller thickness (P=0.03).
Why the study?
Are specific cardiovascular polymorphisms (AGTR1, AGT, ACE, NOS3, GNB3, ADD1) associated with carotid intima-media thickness in a primary care population?
Cross-Sectional (n=618)
Are specific cardiovascular polymorphisms (AGTR1, AGT, ACE, NOS3, GNB3, ADD1) associated with carotid intima-media thickness in a primary care population?
The AGTR1 and ADD1 polymorphisms demonstrate a small, sex-specific association with carotid intima-media thickness in women, suggesting a potential genetic influence on subclinical atherosclerosis.
Answers are grounded in this paper and cite their sources.
AGTR1 and ADD1 variants show sex-specific links to carotid IMT in women; cross-sectional data leave open causal roles and clinical relevance.
OBJECTIVE: In a primary care population covering a broad spectrum of cardiovascular risk (HIPPOCRATES project) the relationship between carotid intima-media thickness (CIMT) and six cardiovascular polymorphisms were analyzed in a cross-sectional study. METHODS: CIMT was assessed in 618 participants, who were genotyped for the AGTR1 (A1166C), AGT (M235T), ACE (4656(rpt)), NOS3 (E298D), GNB3 (C825T) and ADD1 (G460W) polymorphisms. Linear regression analyses were performed to assess the relationship between CIMT and the polymorphisms. RESULTS: The study population included 289 men (46.8%) and 329 (53.2%) women of whom 52.3% were treated with cardiovascular medication. CIMT was significantly associated with age, female sex, use of cardiovascular medication, waist circumference and dyslipidemia. After correction for these covariates, multivariate linear regression analyses showed that only in women the C-allele of AGTR1 was associated with a thicker CIMT (P = 0.03). The T-allele of ADD1 was associated with a smaller CIMT in both men and women, but this only reached statistical significance in women (P = 0.03). CONCLUSION: Although the effect of both genetic variants on CIMT was small, this study showed a statistically significant effect of AGTR1 and ADD1 in women. However, our findings should be viewed as hypothesis-generating and require further confirmation in prospective epidemiological primary care studies.
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Plat et al. (2009) conducted a cross-sectional in Cardiovascular risk (n=618). Cardiovascular polymorphisms (AGTR1 and ADD1) was evaluated on Carotid intima-media thickness (CIMT) (p=0.03). In women, the C-allele of AGTR1 was associated with a thicker carotid intima-media thickness (P=0.03), and the T-allele of ADD1 was associated with a smaller thickness (P=0.03).
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