Why the study?
Does the 460Trp allele of the alpha-adducin gene increase the risk of atherosclerosis, cardiovascular disease, and cerebrovascular disease compared to the Gly460 allele?
Population
6471 subjects of the Rotterdam Study and 1018 subjects of the Rotterdam Scan Study
Comparison
Carriers of the 460Trp allele of the… vs Homozygous carriers of the Gly460 allele
Design
Cohort
Authors
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May support risk stratification in hypertension; leaves open causal role and need for prospective validation.
Does the 460Trp allele of the alpha-adducin gene increase the risk of atherosclerosis, cardiovascular disease, and cerebrovascular disease compared to the Gly460 allele?
The Gly460Trp polymorphism of the alpha-adducin gene is associated with increased risks of atherosclerosis, stroke, and myocardial infarction, particularly in hypertensive individuals.
Rijn et al. (2006) studied this question.
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