Key result
Very high SCORE2/SCORE2-OP risk linked to ~240% higher mortality after severe aortic stenosis valve replacement.
Why the study?
Mortality in patients with severe aortic stenosis remains considerable despite advances in valve interventions, prompting investigation into whether age-appropriate SCORE2 risk classification provides prognostic information after SAVR or TAVI.
Does very high SCORE2/SCORE2-OP risk classification predict all-cause mortality in patients with severe aortic stenosis undergoing transcatheter or surgical aortic valve replacement?
Cohort (n=168)
No
Does very high SCORE2/SCORE2-OP risk classification predict all-cause mortality in patients with severe aortic stenosis undergoing transcatheter or surgical aortic valve replacement?
Answers are grounded in this paper and cite their sources.
Global cardiovascular risk assessment using SCORE2/SCORE2-OP provides independent prognostic information for mid-term mortality in patients with severe aortic stenosis undergoing valve replacement.
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Mammadli et al. (2026) conducted a cohort in Severe aortic stenosis (n=168). Very high SCORE2/SCORE2-OP risk vs. Non-very high SCORE2/SCORE2-OP risk was evaluated on All-cause mortality (HR 3.40, 95% CI 1.11-10.41, p=0.032). Very high SCORE2/SCORE2-OP risk was associated with increased mid-term all-cause mortality in patients with severe aortic stenosis undergoing valve replacement.
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