Key result
Metabolic syndrome in women was associated with significantly increased left ventricular mass index (39.7 vs 29.5 g/m2.7, p=0.01) and carotid intima-media thickness compared to women without metabolic syndrome.
Why the study?
Does the presence and clustering of metabolic syndrome components correlate with adverse changes in left ventricular geometry, function, and arterial stiffness in adults?
Cross-Sectional (n=702)
No
Does the presence and clustering of metabolic syndrome components correlate with adverse changes in left ventricular geometry, function, and arterial stiffness in adults?
Absolute Event Rate: 39.7% vs 29.5%
p-value: p=0.01
Metabolic syndrome clustering is strongly correlated with adverse left ventricular geometric changes, diastolic dysfunction, and arterial stiffness, particularly in women.
MetS clustering may mark subclinical LV and vascular changes especially in women; leaves open whether component modification improves outcomes.
Although metabolic syndrome (MetS) is associated with increased cardiovascular mortality and the development of atherosclerosis, consensus is still lacking on the status of cardiovascular function and geometry in MetS patients. We investigated the relation between MetS and left ventricle (LV) geometry and function, carotid intima-media thickness (IMT) and arterial stiffness in a community-based cohort of 702 adult subjects. Subjects were categorized into three groups according to the number of MetS components present, as defined by the Adult Treatment Panel III guidelines: 1) Absent (0 criteria), 2) Pre-MetS (1-2 criteria) or 3) MetS (> or =3 criteria). In female subjects, LV mass, LV mass/height(2.7), deceleration time, and aortic pulse wave velocity increased, and E/A ration decreased in a stepwise manner across the three groups. These changes were not observed in male subjects. The mean carotid IMT was higher in the MetS group than in the other two groups. The degree of MetS clustering is found to be strongly correlated with geometric eccentricity of LV hypertrophy, diastolic dysfunction and arterial changes irrespective of age and blood pressure status, particularly in females. Waist circumference is found to have the most powerful effect on cardiovascular parameters.
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Ahn et al. (2010) conducted a cross-sectional in Metabolic Syndrome (n=702). Metabolic syndrome vs. Absence of metabolic syndrome was evaluated on Left ventricular mass/height^2.7 in females (p=0.01). Metabolic syndrome in women was associated with significantly increased left ventricular mass index (39.7 vs 29.5 g/m2.7, p=0.01) and carotid intima-media thickness compared to women without metabolic syndrome.
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