Key result
Pharmacogenomic testing using an ACT-predictive risk classification in pediatric cancer patients is projected to reduce mortality risk from anthracycline-induced cardiotoxicity by 17%.
Why the study?
Does pharmacogenomic testing reduce mortality and costs associated with anthracycline-induced cardiotoxicity in pediatric cancer patients?
Does pharmacogenomic testing reduce mortality and costs associated with anthracycline-induced cardiotoxicity in pediatric cancer patients?
Pharmacogenomic testing for anthracycline-induced cardiotoxicity risk in pediatric cancer patients is projected to be cost-saving and reduce mortality.
BACKGROUND: Anthracyclines are a class of highly effective chemotherapeutic drugs commonly used to treat cancer patients. Anthracyclines, however, are associated with the development of serious adverse reactions, including anthracycline-induced cardiotoxicity (ACT). It is not possible, within current practice, to accurately individualize treatment to minimize risk. PROCEDURE: Recently, genetic variants have been associated with the risk of ACT in children. Building on these findings and the related genetic test, a predictive model was developed which classifies pediatric patients by their risk of developing ACT. We assessed the value of this ACT-predictive risk classification in addressing ACT. RESULTS: With current care, the estimated average lifetime cost of ACT is $8,667 per anthracycline-treated patient and approximately 7% of patients are expected to die from ACT. The projected impact of the information from the new predictive model is a 17% reduction in the risk of mortality from ACT and savings of about 6%: lives saved and lower costs. CONCLUSION: The newly identified genetic variants associated with the risk of ACT provide information that allows a more reliable prediction of the risk of ACT for a given patient and can be obtained at a very moderate cost, which is expected to lead to meaningful progress in reducing harm and costs associated with ACT.
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Dionne et al. (2017) studied Childhood cancer treated with anthracyclines. Pharmacogenomic testing (ACT-predictive risk classification) vs. Current care was evaluated on Mortality from anthracycline-induced cardiotoxicity (ACT) and lifetime cost (17% reduction in mortality risk and 6% cost savings). Pharmacogenomic testing using an ACT-predictive risk classification in pediatric cancer patients is projected to reduce mortality risk from anthracycline-induced cardiotoxicity by 17%.
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