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September 6, 2018ACS Applied Materials & InterfacesOpen Access

Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction

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Why the study?

Does a vascularized cardiac patch (BMV-CSC patch) improve cardiomyocyte proliferation and neovascularization compared to conventional CSC patches in a rat model of acute myocardial infarction?

Population

Rat model of acute myocardial infarction and human umbilical vein endothelial cells with human cardiac stem…

Comparison

Vascularized cardiac patch created using… vs Conventional CSC patches and coculture of…

Design

Preclinical

Follow-up

4 weeks (in vivo), 7 days (in vitro)

Key result

In a rat model of acute MI, the BMV-CSC patch significantly increased myocardial capillary density compared to conventional CSC patches at 4 weeks post-treatment.

Authors

TSTeng SuKHKe HuangMDMichael A. Daniele

Discussion

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Overview

Microengineered CSC patches may boost post-MI repair in animals; leaves open clinical translation and human efficacy trials.

Structured PICO

Does a vascularized cardiac patch (BMV-CSC patch) improve cardiomyocyte proliferation and neovascularization compared to conventional CSC patches in a rat model of acute myocardial infarction?

P
Population
Rat model of acute myocardial infarction.
I
Intervention
Vascularized cardiac patch (BMV-CSC patch) created using microfluidic hydrodynamic focusing to construct biomimetic microvessels (BMVs) with HUVECs, encapsulated in a fibrin gel spiked with human CSCs
C
Comparator
Conventional CSC patches (in vivo) and coculture of genuine human CSCs and HUVECs (in vitro)
O
Outcome
Mitotic activities of cardiomyocytes and myocardial capillary density in the peri-infarct regionsurrogate

A novel vascularized cardiac patch integrating biomimetic microvessels and cardiac stem cells significantly enhances cardiomyocyte proliferation and neovascularization after acute myocardial infarction in a rat model.

Cite This Study

Su et al. (2018) studied Acute myocardial infarction. Vascularized cardiac patch (BMV-CSC patch) vs. Conventional CSC patches was evaluated on Myocardial capillary density and cardiomyocyte mitotic activities. In a rat model of acute MI, the BMV-CSC patch significantly increased myocardial capillary density compared to conventional CSC patches at 4 weeks post-treatment.

synapsesocial.com/papers/6a628da57459161287c3c146https://doi.org/10.1021/acsami.8b13571
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemodynamic Contribution of Stem Cell Scaffolding in Acute Injured Myocardium2012 · 30 citations
  2. 2Nanofibrous Collagen Nerve Conduits for Spinal Cord Repair2012 · 151 citations
  3. 3A Blood Vessel Model Constructed from Collagen and Cultured Vascular Cells1986 · 1,240 citations