Key result
In patients with coronary artery disease, the novel START index demonstrated a strong positive correlation with the established cardio-ankle vascular index (r=0.879, p<0.001).
Why the study?
A novel arterial stiffness index, START, was developed based on different physical principles than conventional stiffness parameter beta, but its use in CAD patients needed investigation.
Does the novel START index correlate with the established CAVI for assessing arterial stiffness in patients with coronary artery disease?
Observational (n=353)
No
Does the novel START index correlate with the established CAVI for assessing arterial stiffness in patients with coronary artery disease?
The novel START index for assessing arterial stiffness correlates strongly with the established CAVI in patients with coronary artery disease, suggesting its potential utility in clinical practice.
Answers are grounded in this paper and cite their sources.
START index feasibility in CAD is hypothesis-generating; leaves open clinical adoption pending prospective validation.
Background — Recently, a novel method for assessing arterial stiffness was developed under the name of START (STiffness of ARTeries), which, unlike the conventional stiffness parameter β, is calculated based on other physical principles. Our study aimed to investigate the possibility of using the new START index in patients with coronary artery disease (CAD). Methods — The study included 353 patients with CAD: 277 men and 76 women. Their median age was 57.0 (53.0; 64.0) years. The arterial stiffness was assessed in all subjects using VaSera VS-1000 sphygmomanometer. The novel arterial stiffness index (START) was analyzed retrospectively. We assessed the correlation of cardio-ankle vascular index (CAVI) and START index, as well as each of these indices with risk factors in the entire cohort of those examined, and also separately for men and women. Results — In examined CAD patients, the median value of the CAVI was within the borderline values (8.0-9.0) [5]: 8.3 (7.6; 9.2) on the right side and 8.3 (7.6; 9.2) on the left side. A median value of the START index was 8.3 (7.1; 9.8) on the right and 8.1 (7.0; 9.6) on the left. A strong relationship between CAVI and START was revealed in the total sample (r=0.879, p<0.001). Women exhibited a more pronounced association (r=0.982, p<0.001) than men (r=0.805, p<0.001). For the total sample, we revealed a strong dependence of the indices on age (r=0.4, p<0.001 for CAVI; r=0.36, p<0.001 for the START index). Both stiffness indices exhibited a weak but significant correlation with glomerular filtration rate (GFR) in the entire sample of study subjects (r=-0.168, p=0.003 for CAVI; r=-0.0159, p=0.004 for START). Conclusion — In patients with CAD, the START index was strongly associated with the CAVI throughout the entire cohort, albeit the correlation in women was slightly stronger than in men. Also, these indices had similar associations with clinical factors and age. Strong correlation between these indices is important for the subsequent practical application of the START index. The possibility of using START index in similar clinical situations as the CAVI requires confirmation in further studies.
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An et al. (2023) conducted an observational in Coronary artery disease (n=353). START index vs. Cardio-ankle vascular index (CAVI) was evaluated on Correlation between cardio-ankle vascular index (CAVI) and START index (r=0.879, p=<0.001). In patients with coronary artery disease, the novel START index demonstrated a strong positive correlation with the established cardio-ankle vascular index (r=0.879, p<0.001).
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