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January 1, 2026International Journal of Vascular MedicineOpen Access

Arterial Stiffness and Cognitive Impairment in Patients With Arterial Hypertension: CAVI and haSTART Index

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Why the study?

Increased arterial stiffness is an established CVD risk factor linked to cognitive impairment, but the relationship between CAVI and the haSTART index and their association with cognitive impairment in hypertensive patients required investigation.

Are arterial stiffness indices (CAVI and haSTART) associated with cognitive impairment in patients with arterial hypertension?

Population

128 patients (96 with essential HTN and 32 controls without HTN)

Comparison

Essential HTN vs controls with no history of HTN

Design

Single-center study

Authors

TST. A. SafronovaSMS. É. MukhanovaТВТ. С. Варгина

Discussion

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Overview

Arterial stiffness indices may mark cognitive risk in hypertension but should not yet change practice; leaves open need for longitudinal validation.

Structured PICO

Are arterial stiffness indices (CAVI and haSTART) associated with cognitive impairment in patients with arterial hypertension?

P
Population
128 patients (55 men, 73 women, aged 35-79 years), comprising 96 with essential hypertension devoid of comorbidities and 32 controls with no history of hypertension.
I
Intervention
Assessment of arterial stiffness using cardio-ankle vascular index (CAVI) and STELARI heart-ankle STiffness of ARTeries (haSTART) index.
C
Comparator
Patients without hypertension (controls) and correlation across the cohort.
O
Outcome
Relationship between CAVI and haSTART index, and their association with cognitive impairment assessed via Montreal Cognitive Assessment (MoCA).surrogate

Arterial stiffness, measured by CAVI and the novel haSTART index, is significantly associated with cognitive impairment in patients with hypertension.

Cite This Study

Safronova et al. (2026) studied this question.

synapsesocial.com/papers/6a7045bde71d69abee087e46https://doi.org/10.1155/ijvm/9456777
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