What question did this study set out to answer?

This research aims to analyze the phylogenetic relationships and functional evolution of condensation domain subtypes in non-ribosomal peptide synthetases.

January 1, 2007BMC Evolutionary BiologyOpen Access

Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution

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Authors

CRChristian RauschLudwig-Maximilians-Universität München IHIlka HoofNovo Nordisk (Denmark)TWTilmann WeberNovo Nordisk Foundation

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Implication

Randomized trial analyzes functional evolution of condensation domains in non-ribosomal peptide synthetases, implying implications for peptide synthesis.

Key Points

This research aims to analyze the phylogenetic relationships and functional evolution of condensation domain subtypes in non-ribosomal peptide synthetases.
Reconstructed phylogenetic relationships of NRPS C domain subtypes.
Analyzed sequence motifs of recently discovered subtypes including Dual E/C, DCL, and Starter domains.
Developed profile Hidden Markov Models for sequence motifs to aid in classification.
LC and Starter domains are more closely related than to other C domain subtypes, with differing donor substrates.
Dual E/C and DCL domains share a common ancestor based on phylogenetic data.
Potentials for converting one subtype into another, such as DCL to LCL, for novel peptide products.

Cite This Study

Rausch et al. (2007) studied this question.

synapsesocial.com/papers/6a62917fa10174a79f07c2c3 https://doi.org/10.1186/1471-2148-7-78

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Implication

Randomized trial analyzes functional evolution of condensation domains in non-ribosomal peptide synthetases, implying implications for peptide synthesis.

Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution

Discussion

Member takes

Implication

Key Points

Cite This Study

Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution

Discussion

Member takes

Implication

Key Points

Cite This Study

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