Key result
Morbid obesity in women was associated with significantly lower plasma omentin levels (1.97 ng/mL) compared to lean controls (5.27 ng/mL), which inversely correlated with metabolic syndrome.
Cross-Sectional (n=71)
Yes
Answers are grounded in this paper and cite their sources.
Omentin reduction associates with metabolic syndrome in morbid obesity; leaves causal role and clinical utility open for prospective study.
BACKGROUND: Vaspin and omentin are recently described molecules that belong to the adipokine family and seem to be related to metabolic risk factors. The objectives of this study were twofold: to evaluate vaspin and omentin circulating levels and mRNA expression in subcutaneous and visceral adipose tissues in non-diabetic morbidly obese women; and to assess the relationship of vaspin and omentin with anthropometric and metabolic parameters, and other adipo/cytokines. DESIGN: We analysed vaspin and omentin circulating levels in 71 women of European descent (40 morbidly obese [BMI≥40 kg/m2] and 31 lean [BMI≤25]). We assessed vaspin and omentin gene expression in paired samples of visceral and subcutaneous abdominal adipose tissue from 46 women: 40 morbidly obese and 6 lean. We determined serum vaspin and plasma omentin levels with an Enzyme-Linked Immunosorbent Assay and adipose tissue mRNA expression by real time RT-PCR. RESULTS: Serum vaspin levels in the morbidly obese were not significantly different from those in controls. They correlated inversely with levels of lipocalin 2 and interleukin 6. Vaspin mRNA expression was significantly higher in the morbidly obese, in both subcutaneous and visceral adipose tissue.Plasma omentin levels were significantly lower in the morbidly obese and they correlated inversely with glucidic metabolism parameters. Omentin circulating levels, then, correlated inversely with the metabolic syndrome (MS). Omentin expression in visceral adipose tissue was significantly lower in morbidly obese women than in controls. CONCLUSIONS: The present study indicates that vaspin may have a compensatory role in the underlying inflammation of obesity. Decreased omentin circulating levels have a close association with MS in morbidly obese women.
No takes yet. Share an insight, caveat, or question.
Auguet et al. (2011) conducted a cross-sectional in Morbid Obesity (n=71). Morbid obesity (BMI > 40 kg/m2) vs. Lean controls (BMI < 25 kg/m2) was evaluated on Plasma omentin levels (ng/mL) (p=<0.05). Morbid obesity in women was associated with significantly lower plasma omentin levels (1.97 ng/mL) compared to lean controls (5.27 ng/mL), which inversely correlated with metabolic syndrome.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: