Key result
In Japanese patients with non-valvular atrial fibrillation, baseline systolic blood pressure <114 mmHg was associated with higher all-cause mortality (HR 1.43; 95% CI 1.13-1.81).
Why the study?
This study aimed to investigate the impact of baseline blood pressure on adverse outcomes in patients with AF using a pooled analysis from a large Japanese cohort.
Does baseline blood pressure impact the risk of adverse outcomes in Japanese patients with non-valvular atrial fibrillation?
Population
15 019 Japanese non-valvular AF patients with baseline BP values
Comparison
Baseline systolic BP quartiles or systolic BP >=150 mmHg vs <150 mmHg
Design
Pooled cohort analysis of five major AF registries
Follow-up
730 days
Authors
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Baseline BP may associate with outcomes in Japanese AF cohorts; leaves open optimal targets for this population.
Cohort (n=15,019)
Yes
Does baseline blood pressure impact the risk of adverse outcomes in Japanese patients with non-valvular atrial fibrillation?
Hazard Ratio: 1.43 (95% CI 1.13–1.81)
In Japanese patients with non-valvular AF, baseline systolic BP <114 mmHg is associated with increased mortality, while systolic BP ≥150 mmHg increases the risk of major bleeding.
Kodani et al. (2022) conducted a cohort in Non-valvular atrial fibrillation (n=15,019). Baseline systolic blood pressure <114 mmHg vs. Third quartile of systolic blood pressure was evaluated on All-cause death (HR 1.43, 95% CI 1.13-1.81). In Japanese patients with non-valvular atrial fibrillation, baseline systolic blood pressure <114 mmHg was associated with higher all-cause mortality (HR 1.43; 95% CI 1.13-1.81).
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