Key result
In Japanese patients with non-valvular atrial fibrillation not receiving anticoagulation therapy, the overall incidence of ischemic stroke was 13.3 per 1,000 person-years, with higher rates observed in those with a CHADS2 score ≥2.
Why the study?
What is the incidence rate of ischemic stroke in Japanese patients with non-valvular atrial fibrillation not receiving anticoagulation therapy?
Observational (n=3,588)
Yes
What is the incidence rate of ischemic stroke in Japanese patients with non-valvular atrial fibrillation not receiving anticoagulation therapy?
Japanese NVAF patients not on anticoagulation have a relatively low incidence of ischemic stroke unless their CHADS2 score is ≥ 2, with prior stroke/TIA, advanced age, and hypertension being independent risk factors.
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Low stroke rates in low-CHADS2 Japanese NVAF without anticoagulation support cautious risk stratification; leaves open prospective validation before practice change.
Suzuki et al. (2014) conducted an observational in Non-valvular atrial fibrillation (NVAF) (n=3,588). No anticoagulation therapy was evaluated on Incidence of ischemic stroke (95% CI 10.5-16.8). In Japanese patients with non-valvular atrial fibrillation not receiving anticoagulation therapy, the overall incidence of ischemic stroke was 13.3 per 1,000 person-years, with higher rates observed in those with a CHADS2 score ≥2.
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