In Japanese patients with non-valvular atrial fibrillation not receiving anticoagulation therapy, the overall incidence of ischemic stroke was 13.3 per 1,000 person-years, with higher rates observed in those with a CHADS2 score ≥2.
Observational (n=3,588)
Yes
What is the incidence rate of ischemic stroke in Japanese patients with non-valvular atrial fibrillation not receiving anticoagulation therapy?
Japanese NVAF patients not on anticoagulation have a relatively low incidence of ischemic stroke unless their CHADS2 score is ≥ 2, with prior stroke/TIA, advanced age, and hypertension being independent risk factors.
BACKGROUND: The incidence rate of ischemic stroke in Japanese non-valvular atrial fibrillation (NVAF) patients without anticoagulation therapy remains unclear. METHODS AND RESULTS: We performed a pooled analysis of 3,588 patients from the Shinken Database (n=1,099), J-RHYTHM Registry (n=1,002), and Fushimi AF Registry (n=1,487) to determine the incidence rate of ischemic stroke in Japanese NVAF patients without anticoagulation therapy. Average patient age was 68.1 years. During the follow-up period (total, 5,188 person-years; average, 1.4 years), 69 patients suffered from ischemic stroke (13.3 per 1,000 person-years; 95% confidence intervals CI: 10.5-16.8). The incidence rates of ischemic stroke were 5.4, 9.3, and 24.7 per 1,000 person-years and 5.3, 5.5, and 18.4 per 1,000 person-years in patients with low (0), intermediate (1), and high (≥ 2) CHADS2 and CHA2DS2-VASc scores, respectively. History of ischemic stroke or transient ischemic attack (hazard ratio HR, 3.25; 95% CI: 1.86-5.67), age ≥ 75 years (HR, 2.31; 95% CI: 1.18-4.52), and hypertension (HR, 1.69; 95% CI: 1.01-2.86) were independent risk factors for ischemic stroke. CONCLUSIONS: A low incidence rate of ischemic stroke was observed in Japanese NVAF patients except for those with CHADS2 score ≥ 2. In this pooled analysis, history of ischemic stroke or transient ischemic attack, advanced age, and hypertension were identified as independent risk factors for ischemic stroke.
Suzuki et al. (Thu,) conducted a observational in Non-valvular atrial fibrillation (NVAF) (n=3,588). No anticoagulation therapy was evaluated on Incidence of ischemic stroke (95% CI 10.5-16.8). In Japanese patients with non-valvular atrial fibrillation not receiving anticoagulation therapy, the overall incidence of ischemic stroke was 13.3 per 1,000 person-years, with higher rates observed in those with a CHADS2 score ≥2.