Key result
Increased fasting blood glucose (OR 1.918) and decreased HDL-C (OR 1.794) were significantly associated with suicide attempts in young, drug-naive patients with first-episode major depressive disorder.
Why the study?
Previous studies examined the relationship between suicide attempts and metabolism in elderly patients with MDD, but overlooked young people.
Are metabolic indicators associated with suicide attempts in young patients with first-episode and drug-naive major depressive disorder?
Comparison
128 patients with suicide attempts vs non-suicide attempters
Design
Cross-sectional study
Authors
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Metabolic markers may relate to suicide risk in young MDD; hypothesis-generating and requires prospective validation before any clinical role.
Cross-Sectional (n=740)
No
Are metabolic indicators associated with suicide attempts in young patients with first-episode and drug-naive major depressive disorder?
Odds Ratio: 1.918 (95% CI 1.104–3.331)
p-value: p=0.021
Increased fasting blood glucose and decreased HDL-C are associated with suicide attempts in young patients with major depressive disorder.
Zhao et al. (2020) conducted a cross-sectional in Major depressive disorder (n=740). Increased fasting blood glucose vs. Normal fasting blood glucose was evaluated on Suicide attempts (OR 1.918, 95% CI 1.104-3.331, p=0.021). Increased fasting blood glucose (OR 1.918) and decreased HDL-C (OR 1.794) were significantly associated with suicide attempts in young, drug-naive patients with first-episode major depressive disorder.
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