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The simultaneous occurrence of psoriasis driven by type 1 helper T (Th1) cells and 17 helper T (Th17) cells and atopic eczema dominated by type 2 helper T (Th2) is rare. Here, we describe three patients with co-occurring psoriasis and atopic with an antagonistic course and distinct T-cell infiltrates in lesions from and those from atopic eczema. Sensitized patients with psoriasis had a reaction epicutaneous allergen challenge, with clinically and histologically verified lesions containing a large number of allergen-reactive T cells. These findings a causative role for T cells triggered by specific antigens in both psoriasis atopic eczema.
Eyerich et al. (Wed,) studied this question.