Key result
Cryo-electron microscopy revealed that RNA-dependent RNA polymerases and associated RNAs exhibit a pseudo-D3 symmetric organization in both nontranscribing and transcribing cypoviruses.
Cryo-EM reveals the pseudo-D3 symmetric organization of RdRps and associated RNAs in cypoviruses, providing insight into dsRNA virus replication and transcription mechanisms.
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Reveals viral transcription machinery; leaves open any clinical or therapeutic translation.
Liu et al. (2015) studied dsRNA virus (cypovirus). Cryo-electron microscopy and symmetry-mismatch reconstruction was evaluated on Structures of RdRps and associated RNAs. Cryo-electron microscopy revealed that RNA-dependent RNA polymerases and associated RNAs exhibit a pseudo-D3 symmetric organization in both nontranscribing and transcribing cypoviruses.
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