Urothelial carcinoma management in elderly or unfit patients

Strategies to improve cancer care in the field of urothelial carcinoma (UC) in the elderly or in patients unfit to receive cisplatin treatment are urgently needed. This effort requires multidisciplinary collaboration to provide the best care for these patients. An international multidisciplinary summit was held in Geneva on April 11th 2015 to discuss unmet medical needs in urothelial cancer. Key topics covered in the meeting included defining difficult-to-treat UC patients and the challenges encountered with both surgical and systemic treatment in these patients. The delegates discussed potential therapies, from neoadjuvant treatment to combinations or sequential regimens, maintenance therapy up to second-line management, and future treatment opportunities that could improve on current patient outcomes. Molecular specificities and future perspectives of UC were also discussed. Each individual topic of the meeting is outlined in the chapters below.