Key result
Obesity was associated with a higher unadjusted prevalence of unrecognized myocardial scar compared to normal weight (13.7% vs 9.1%, p=0.015), but this difference was no longer significant after adjusting for Framingham risk factors.
Cross-Sectional (n=1,337)
Blinded corelab
Yes
Absolute Event Rate: 13.7% vs 9.1%
p-value: p=0.015
Obesity shows no independent link to unrecognized MI after risk adjustment; leaves open whether CMR refines obesity-related risk beyond Framingham factors.
Background Obesity is a major public health issue given its high cardiovascular morbidity and mortality. However, whether obesity predicts cardiovascular disease independent from traditional Framingham risk factors is controversial [1]. Delayed-enhancement CMR (DE-CMR) allows for sensitive and specific detection of unrecognized MI, which appears associated with adverse prognosis similar to clinically recognized MI. We examined the relationship between obesity and the prevalence of unrecognized myocardial scar (UScar) and/ or unrecognized MI (UMI) as determined by DE-CMR.
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Jensen et al. (2013) conducted a cross-sectional in Suspected coronary artery disease (n=1,337). Obesity (BMI ≥25 kg/m2) vs. Normal weight (BMI <25 kg/m2) was evaluated on Prevalence of unrecognized myocardial scar (UScar) (p=0.015). Obesity was associated with a higher unadjusted prevalence of unrecognized myocardial scar compared to normal weight (13.7% vs 9.1%, p=0.015), but this difference was no longer significant after adjusting for Framingham risk factors.
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