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This study aims to explore the effects of mesenchymal stem cells on fibroblast migration and wound healing in chronic wound patients.

Stimulation of Skin and Wound Fibroblast Migration by Mesenchymal Stem Cells Derived from Normal Donors and Chronic Wound Patients

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This study aims to explore the effects of mesenchymal stem cells on fibroblast migration and wound healing in chronic wound patients.
In vitro scratch assay used labeled mesenchymal stem cells and fibroblasts from normal donors and chronic wound patients.
Modified Boyden chamber assay employed to assess the impact of soluble factors on fibroblast migration.
Mesenchymal stem cells significantly enhance fibroblast migration in a dose-dependent manner.
Chronic wound patient fibroblasts showed deficiencies compared to those from normal donors.
Findings suggest potential targeted therapies utilizing bone marrow-derived mesenchymal stem cells for improved wound healing.

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Randomized trial investigates fibroblast migration influenced by mesenchymal stem cells in chronic wound patients, suggesting targeted therapies.

Rodriguez-Menocal et al. (2012) studied this question.

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Randomized trial investigates fibroblast migration influenced by mesenchymal stem cells in chronic wound patients, suggesting targeted therapies.