Key result
Allopurinol attenuated diabetes-induced myocardial oxidative stress, apoptosis, and fibrosis, improving systolic and diastolic performance in mice with diabetic cardiomyopathy.
Why the study?
Does allopurinol improve cardiac dysfunction and reduce oxidative stress in a mouse model of diabetic cardiomyopathy?
Does allopurinol improve cardiac dysfunction and reduce oxidative stress in a mouse model of diabetic cardiomyopathy?
Xanthine oxidase inhibition with allopurinol improves cardiac dysfunction and reduces oxidative stress and fibrosis in a mouse model of type 1 diabetic cardiomyopathy.
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Does not support clinical use in diabetic cardiomyopathy; leaves open translation of mouse benefits to humans.
Rajesh et al. (2008) studied diabetic cardiomyopathy. allopurinol vs. placebo was evaluated on cardiac dysfunction, oxidative-nitrosative stress, apoptosis, PARP activity and fibrosis. Allopurinol attenuated diabetes-induced myocardial oxidative stress, apoptosis, and fibrosis, improving systolic and diastolic performance in mice with diabetic cardiomyopathy.
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