Key result
Allopurinol 300 mg for 1 month significantly increased the mean forearm blood flow response to acetylcholine by 30% (3.16 vs 2.54 mL/100mL/min; P=0.012) in type 2 diabetics with mild hypertension.
Why the study?
Does allopurinol improve endothelial function in patients with type 2 diabetes and mild hypertension?
Population
23 subjects
Comparison
Allopurinol 300 mg for 1 month vs Placebo for 1 month
Design
RCT, randomized, placebo-controlled
Follow-up
1 month
Authors
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Allopurinol may enhance endothelial function in type 2 diabetes with mild hypertension; extends xanthine oxidase inhibition data to this population.
RCT (n=23)
randomized
Does allopurinol improve endothelial function in patients with type 2 diabetes and mild hypertension?
Mean Difference: 0.62 (95% CI 0.14–1.3)
Absolute Event Rate: 3.16% vs 2.54%
p-value: p=0.012
Allopurinol improves endothelial dysfunction to near-normal levels in patients with type 2 diabetes and mild hypertension, likely by reducing free radical generation via xanthine oxidase inhibition.
Butler et al. (2000) conducted an RCT in Type 2 diabetes with mild hypertension (n=23). Allopurinol vs. Placebo was evaluated on mean forearm blood flow response to acetylcholine (30% increase, 95% CI 0.14, 1.30, p=0.012). Allopurinol 300 mg for 1 month significantly increased the mean forearm blood flow response to acetylcholine by 30% (3.16 vs 2.54 mL/100mL/min; P=0.012) in type 2 diabetics with mild hypertension.
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