Key result
Each 1-MET higher cardiorespiratory fitness was associated with an 8% lower risk of all-cause mortality and a 9% lower risk of cardiovascular mortality over a median 9.9 years of follow-up.
Why the study?
Cardiorespiratory fitness is associated with mortality and cardiovascular disease, but assessing it in the population is challenging.
Does higher cardiorespiratory fitness reduce the risk of all-cause and cardiovascular mortality?
Population
79,981 participants in the UK Biobank study
Comparison
Per 1-metabolic equivalent difference in cardiorespiratory fitness
Authors
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Supports novel CRF estimation for risk stratification; hypothesis-generating without randomized confirmation.
Cohort (n=79,981)
Yes
Does higher cardiorespiratory fitness reduce the risk of all-cause and cardiovascular mortality?
Hazard Ratio: 0.92 (95% CI 0.89–0.95)
A novel framework for estimating cardiorespiratory fitness demonstrates that each 1-MET increase in fitness is associated with an 8% reduction in all-cause mortality and a 9% reduction in cardiovascular mortality, suggesting previous methods underestimated the health benefits of fitness.
Gonzales et al. (2021) conducted a cohort in General population (n=79,981). Cardiorespiratory fitness (per 1-MET difference) vs. Lower cardiorespiratory fitness was evaluated on All-cause mortality (8% lower risk, 95% CI 0.89-0.95). Each 1-MET higher cardiorespiratory fitness was associated with an 8% lower risk of all-cause mortality and a 9% lower risk of cardiovascular mortality over a median 9.9 years of follow-up.
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