Key result
Autonomic dysfunction is proposed as the major contributor to the low levels of work capacity and V˙O2peak observed in individuals with Down syndrome.
Why the study?
Is autonomic dysfunction the major contributor to low work capacity in individuals with Down syndrome?
Is autonomic dysfunction the major contributor to low work capacity in individuals with Down syndrome?
Autonomic dysfunction is proposed as the primary mechanism explaining the commonly observed low work capacity and chronotropic incompetence in individuals with Down syndrome.
Autonomic dysfunction may contribute to low work capacity in Down syndrome; leaves open need for confirmatory trials before guiding interventions.
In Brief Low work capacity and V˙O2peak commonly are described phenomena in Down syndrome. This is accompanied by chronotropic incompetence and a high incidence of obesity. Although many causes of low work capacity in Down syndrome have been proposed, little scientific support exists. Our working hypothesis is that autonomic dysfunction is the major contributor to the low levels of work capacity in this population. We provide evidence for our hypothesis that low work capacity in Down syndrome can be explained by autonomic dysfunction.
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Fernhall et al. (2013) conducted a review in Down syndrome. Autonomic dysfunction was evaluated on Low work capacity. Autonomic dysfunction is proposed as the major contributor to the low levels of work capacity and V˙O2peak observed in individuals with Down syndrome.
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