Why the study?
Do individuals with Down syndrome without congenital heart disease exhibit altered autonomic cardiac regulation in response to orthostatic stress compared to healthy controls?
Do individuals with Down syndrome without congenital heart disease exhibit altered autonomic cardiac regulation in response to orthostatic stress compared to healthy controls?
Individuals with Down syndrome without congenital heart disease exhibit impaired autonomic cardiac regulation, potentially explaining their chronotropic incompetence during exercise.
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Blunted orthostatic autonomic responses in Down syndrome may underlie chronotropic incompetence; hypothesis-generating and requires prospective confirmation.
Iellamo et al. (2005) studied this question.
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