Key result
Young men with Down syndrome show lower SBP and altered hormonal responses during autonomic testing.
Why the study?
Are hormonal and autonomic responses to autonomic stimulation altered in young men with Down syndrome compared to controls?
Case-Control (n=22)
No
Are hormonal and autonomic responses to autonomic stimulation altered in young men with Down syndrome compared to controls?
p-value: p=<0.05
Young men with Down syndrome exhibit altered hormonal and vascular responses to autonomic provocation tests, which may limit their physiological adaptations to stress.
May suggest impaired stress adaptation in Down syndrome; hypothesis-generating and requires prospective validation before clinical use.
Background: Down syndrome (DS) population frequently presents autonomic and hormonal dysfunctions that have not been concurrently investigated, and yet could limit adaptations to stress. Methods:We compared 11 control (CONT) and 11 DS adult subjects during three autonomic stimulation tests.Heart rate, blood pressure and hormonal concentrations were measured continuously during these tests.Results: DS subjects showed lower systolic blood pressure in the 3 tests (p<0.05) and blunted baroreflex sensitivity in 2 tests.Handgrip test induced increased heart rate (p<0.001)systolic blood pressure (p<0.01) and norepinephrine (p<0.05) in CONT only.During cold pressor test, ACTH and norepinephrine concentrations were higher during immersion than at rest (p<0.01 and p<0.001 respectively) in DS only.During head-up tilt test, ACTH and cortisol concentrations were higher in DS in both positions (p<0.05). Conclusion:These results support the hypothesis of altered hormonal and vascular responses to autonomic provocation tests in DS subjects.
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Dumortier et al. (2018) conducted a case-control in Down syndrome (n=22). Down syndrome vs. Healthy controls without Down syndrome was evaluated on Systolic blood pressure during autonomic stimulation tests (p=<0.05). Young men with Down syndrome demonstrated altered hormonal and vascular responses to autonomic provocation tests, including significantly lower systolic blood pressure across all tests compared to healthy controls.
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