Key result
Very low HDL-cholesterol is the subject of this systematic review and meta-analysis protocol, which outlines the methodology for future research without reporting clinical results.
Why the study?
No systematic analyses or well-conducted meta-analyses evaluate the relationship between very low HDL-C and stroke across different ages and sexes.
Does very low HDL-C increase the risk of peripheral artery disease in adults aged 34 to 70 years?
Systematic Review
Does very low HDL-C increase the risk of peripheral artery disease in adults aged 34 to 70 years?
This protocol outlines a planned systematic review and meta-analysis to evaluate the association between very low HDL-cholesterol levels and the risk of peripheral artery disease in adults aged 34 to 70 years.
Protocol for very low HDL-C and PAD meta-analysis; leaves open the association in adults 34-70 years.
Purpose of review: HDL-C is believed to retard the formation of atherosclerotic lesions by removing excess cholesterol from cells and preventing endothelial dysfunction. However, there are no systematic analyses or well-conducted meta-analyses to evaluate the relationship between very low HDL-Cand stroke. Patients with peripheral artery disease (PAD) have been found to suffer from diabetes, obesity, lipid abnormalities, including elevated levels of total and LDL-cholesterol as well as triglyceride levels. The aim of this study is to examine this association of very low HDL-Cwith stroke in different ages and sex.
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Roever et al. (2019) conducted a systematic review in Peripheral artery disease. Very low HDL-cholesterol vs. >40 mg/dL was evaluated on Peripheral artery disease (PAD). Very low HDL-cholesterol is the subject of this systematic review and meta-analysis protocol, which outlines the methodology for future research without reporting clinical results.
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