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December 20, 2021BiomedicinesOpen Access

Inverse Association between High-Density Lipoprotein Cholesterol and Adverse Outcomes among Acute Ischemic Stroke Patients with Diabetes Mellitus

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Key result

Lowest HDL-C quintile linked to ~59% higher 1-year recurrent stroke risk versus highest quintile.

  • HR 1.59
  • 95% CI 1.12-2.25
  • n=3,824

Why the study?

Data on the association between HDL-C levels and adverse outcomes in patients with diabetes mellitus remain limited and controversial.

Does low HDL-C increase the risk of recurrent stroke and MACE in acute ischemic stroke patients with diabetes mellitus?

Population

3824 acute ischemic stroke patients with diabetes mellitus from the Third China National Stroke Registry

Comparison

Quintiles of HDL-C levels

Design

Registry-based cohort study

Follow-up

1 year

Authors

GHGuoliang HuCapital UniversityYPYuesong PanVascular MedicineMWMengxing WangCapital Medical University

Discussion

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Member takes

Implication

Low HDL-C levels are associated with a significantly higher risk of recurrent stroke and MACE within 1 year in acute ischemic stroke patients with diabetes mellitus.

Study Design

Type

Cohort (n=3,824)

Multicenter

Yes

Structured PICO

Does low HDL-C increase the risk of recurrent stroke and MACE in acute ischemic stroke patients with diabetes mellitus?

P
Population
3,824 acute ischemic stroke patients with diabetes mellitus (mean age 62.7 years, 34.2% women) from a national registry, followed for 1 year.
E
Exposure
Low HDL-C levels (lowest quintile)
C
Comparator
High HDL-C levels (highest quintile)
O
Outcome
Recurrent stroke and major adverse cardiovascular events (MACEs) within 1 yearhard clinical

Main Result

Hazard Ratio: 1.59 (95% CI 1.12–2.25)

Low HDL-C levels are associated with a significantly higher risk of recurrent stroke and MACE within 1 year in acute ischemic stroke patients with diabetes mellitus.

Cite This Study

Hu et al. (2021) conducted a cohort in Acute ischemic stroke with diabetes mellitus (n=3,824). Lowest quintile of HDL-C vs. Highest quintile of HDL-C was evaluated on Recurrent stroke within 1 year (HR 1.59, 95% CI 1.12-2.25). The lowest quintile of HDL-C was associated with a higher risk of recurrent stroke (HR 1.59; 95% CI 1.12-2.25) and MACEs (HR 1.53; 95% CI 1.09-2.15) at 1 year compared to the highest quintile.

synapsesocial.com/papers/6aa3530e22af0bded4f421cahttps://doi.org/10.3390/biomedicines9121947
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lipid levels achieved after a first myocardial infarction and the prediction of recurrent atherosclerotic cardiovascular disease2019 · 19 citations
  2. 2Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.1993 · 12,478 citations
  3. 3Impact of Mean and Variability of High‐Density Lipoprotein‐Cholesterol on the Risk of Myocardial Infarction, Stroke, and Mortality in the General Population2020 · 47 citations
  4. 4Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association2019 · 7,608 citations
  5. 5Low HDL Cholesterol Is Associated With the Risk of Stroke in Elderly Diabetic Individuals2009 · 44 citations