Matrix metalloproteinase-9 regulates pathological remodeling in cardiovascular disease, with both its deletion and cell-specific overexpression showing beneficial effects in animal models.
Matrix metalloproteinase (MMP)-9, one of the most widely investigated MMPs, regulates pathological remodeling processes that involve inflammation and fibrosis in cardiovascular disease. MMP-9 directly degrades extracellular matrix (ECM) proteins and activates cytokines and chemokines to regulate tissue remodeling. MMP-9 deletion or inhibition has proven overall beneficial in multiple animal models of cardiovascular disease. As such, MMP-9 expression and activity is a common end point measured. MMP-9 cell-specific overexpression, however, has also proven beneficial and highlights the fact that little information is available on the underlying mechanisms of MMP-9 function. In this review, we summarize our current understanding of MMP-9 physiology, including structure, regulation, activation, and downstream effects of increased MMP-9. We discuss MMP-9 roles during inflammation and fibrosis in cardiovascular disease. By concentrating on the substrates of MMP-9 and their roles in cardiovascular disease, we explore the overall function and discuss future directions on the translational potential of MMP-9 based therapies.
Yabluchanskiy et al. (Fri,) conducted a review in Cardiovascular disease. Matrix metalloproteinase-9 (MMP-9) was evaluated. Matrix metalloproteinase-9 regulates pathological remodeling in cardiovascular disease, with both its deletion and cell-specific overexpression showing beneficial effects in animal models.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: