Key result
Matrix metalloproteinases are implicated in cardiovascular disease pathogenesis and represent promising therapeutic targets, though clinical translation is limited by off-target effects.
Why the study?
Clinical translation of MMP-targeting therapies in cardiovascular diseases remains challenging due to off-target effects and complex regulatory mechanisms.
Design
Review
Authors
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MMPs may drive CVD progression; leaves open targeted inhibition as therapy pending prospective trials.
This review highlights the pathophysiological roles of matrix metalloproteinases in cardiovascular diseases and their potential as therapeutic targets, while noting the challenges of off-target effects in clinical translation.
Tănase et al. (2025) conducted a review in Cardiovascular Disease. Matrix metalloproteinases (MMPs) targeted therapies was evaluated. Matrix metalloproteinases are implicated in cardiovascular disease pathogenesis and represent promising therapeutic targets, though clinical translation is limited by off-target effects.
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